Publication: Mapping cis-regulatory chromatin contacts in neural cells links neuropsychiatric disorder risk variants to target genes

PubMed ID: 31367015

Citation: Song M, Yang X, Ren X, et al. Mapping cis-regulatory chromatin contacts in neural cells links neuropsychiatric disorder risk variants to target genes. Nat Genet. 2019;51(8):1252-1262. doi:10.1038/s41588-019-0472-1

Funding: We thank Anthony Schmitt and Bing Ren (Ludwig Institute for Cancer Research, University of California, San Diego) for sharing pcHi-C probes and the pcHi-C protocol. Genomic analysis of the WTC11 line in this study was made possible by the whole-genome sequencing data generated by the Allen Institute for Cell Science. We thank the Institute and its founder Paul G. Allen for making this work possible. We thank Gary Hon (University of Texas Southwestern Medical Center) and Steven Henikoff (Fred Hutchinson Cancer Research Center, Howard Hughes Medical Institute) for providing reagents. We acknowledge the ENCODE Consortium and Bradley Bernstein’s laboratory for generating the ChIP-seq data for astrocytes used in this study. We thank N. Ahituv, Y. Guo, R. D. Hawkins, M. McManus, and B. Ren for providing critical feedback on the manuscript. We thank Y. Qu for her contributions to the illustrations for Figure 1. This work was made possible in part by NIH-NEI P30EY002162 (Core Grant for Vision Research and the Research to Prevent Blindness Unrestricted Grant). This work was supported by the National Institutes of Health (NIH) grants R01AG057497 to Y.S., L.G., and H.S., R01EY027789 and UM1HG009402 to Y.S., the UCSF Weill Institute for Neuroscience Innovation Award, the Hillblom Foundation, and the American Federation for Aging Research New Investigator Award in Alzheimer’s Disease to Y.S., R01EY028249, R01HL130533, R01-HL13535801 to B.R.C., P01NS097206 and U19MH106434 to H.S., and R01MH105128, R35NS097370, and U19AI131130 to G.L.M. M.S. is supported by T32GM007175. F.J. is supported by T32GM007309.