Publication: Genetic analysis of the human microglial transcriptome across brain regions, aging and disease pathologies

PubMed ID: 34992268

Citation: Lopes KP, Snijders GJL, Humphrey J, et al. Genetic analysis of the human microglial transcriptome across brain regions, aging and disease pathologies. Nat Genet. 2022;54(1):4-17. doi:10.1038/s41588-021-00976-y

Funding: We thank members of the Raj and de Witte labs for their feedback on the manuscript. The authors thank the teams of the Netherlands Brain Bank and the Mount Sinai Neuropathology Brain Bank and Research CoRE for their services. We thank the study participants for their generous gifts of brain donation. The microglia were isolated through the efforts of a large team and we would like to thank Manja Litjens, Roland D. van Dijk, Alba Fernández-Andreu, Paul R. Ormel, Hans C. van Mierlo, Y. He, Stephanie Gumbs, Miriam E van Strien, Saskia Burm, Vanessa Donega, and Elly M. Hol for all their contributions to this effort. The authors thank Michael Chao for his assistance with genotyping QC. This work was supported in part through the computational and data resources and staff expertise provided by Scientific Computing at the Icahn School of Medicine at Mount Sinai. Research reported in this paper was supported by the Office of Research Infrastructure of the National Institutes of Health under award number S10OD026880. T.R. is supported by grants from the US National Institutes of Health (NIH) NIA R21-AG063130, NIA R01-AG054005, NIA U01-AG068880, NIA RF1-AG065926, NIA R56-AG055824, and NINDS R01-NS116006. G.S. was supported through ZonMw and the foundation “De Drie Lichten” in the Netherlands. E.N. was supported by Ramon Areces fellowship. The funders had no role in study design, data collection and analysis, decision to publish or preparation of the manuscript.